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KMID : 0358420070500081100
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Korean Journal of Obstetrics and Gynecology
2007 Volume.50 No. 8 p.1100 ~ p.1106
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The clinicopathological relevance of Poly(ADP-ribose)polymerase(PARP)expression in epithelial ovarian cancer
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Shin Su-Il
Kim Jeong-Tae
Choi Kyung-Un
Lee Chang-Hun
Jeong Hye-In
Suh Dong-Soo
Yoon Man-Soo
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Abstract
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Objective: To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.
Methods: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining.
Results: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413).
Conclusion: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer
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KEYWORD
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PARP, Epithelial ovarian cancer
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